Question 19#

Menetrier disease is characterized by:

a. Hypertrophic gastric folds and hypoproteinemia
b. A tortuous submucosal congenital arteriovenous malformation
c. Gastric antral vascular ectasia
d. Epithelial hyperplasia and hypergastrinemia

Correct Answer is A


There are two clinical syndromes characterized by epithelial hyperplasia and giant gastric folds: ZES and Menetrier disease. The latter is characteristically associated with proteinlosing gastropathy and hypochlorhydria. A few patients with these unusual diseases have been successfully treated with the epidermal growth factor receptor blocking monoclonal antibody cetuximab. There may be an increased risk of gastric cancer with this disease, and gastric resection may be indicated for bleeding, severe hypoproteinemia, or cancer. The other options describe Dieulafoy lesions, watermelon stomach, and ZES, respectively.