Internationale Contre le Cancer (AJCC/UICC) sarcoma staging system?A. Tumor size
The seventh edition of the American Joint Committee on Cancer (AJCC) staging system for soft tissue sarcomas is based on histologic grade of aggressiveness, tumor size and depth, and the presence of nodal or distant metastases. Histologic grade is the most important prognostic factor for patients with soft tissue sarcoma. The features that define grade are cellularity, differentiation (good, moderate, or poor/anaplastic), pleomorphism, necrosis (absent, <50%, or ≥50%), and number of mitoses per high-power field (<10, 10-19, or ≥20).