Surgery>>>>>Soft Tissue Sarcomas
Question 4#

All of the following are known molecular pathogenic events in sarcoma EXCEPT:

A. Chromosomal translocations
B. Oncogene amplification
C. Complex genomic rearrangements
D. Epigenetic suppression

Correct Answer is D


In general, sarcomas resulting from identifiable molecular events tend to occur in younger patients with histology suggesting a clear line of differentiation. The identifiable molecular events include point mutations, translocations causing overexpression of an autocrine grow factor, and oncogenic fusion transcription factor producing a cellular environment prone to malignant transformation. In contrast, sarcomas without identifiable genetic changes or expression profile signatures tend to occur in older patients and exhibit pleomorphic cytology and p53 dysfunction.