Surgery>>>>>Gynecology
Question 1#

Concerning human papillomavirus (HPV) vaccination, which of the following is FALSE?

A) Two HPV vaccines have been developed and approved by the U.S. Food and Drug Administration (FDA)
B) Both vaccines generate high concentrations of neutralizing antibodies to HPV Ll protein
C) Prospective randomized clinical trials have demonstrated that vaccination prevents nearly 100% of HPV subtype-specific precancerous cell changes
D) HPV immunizations prevents 90% of all cervical cancers

Correct Answer is D

Comment:

Two human papillomavirus (HPV) vaccines have been developed and approved by the U.S. Food and Drug Administration (FDA). Vaccination generates high concentrations of neutralizing antibodies to HPV Ll protein, the antigen in both vaccines. Several randomized clinical trials involving approximately 35,000 young women have shown that both Gardasil and Cervarix prevent nearly 100% of the HPV subtype-specific precancerous cervical cell changes for up to 4 years after vaccination among women who were not infected at the time of vaccination. Cervical cancer screening continues to play an important role in detection and treatment of cervical intraepithelial neoplasia (CIN) II/III and prevention of cervical cancer in these high-risk patients. Cervical cancer screening continues to be of great importance since HPV immunization will not prevent approximately 25 to 30% of cervical cancers in HPV-na'ive women and does not protect against the development of cancer in women already infected with carcinogenic HPV types.