Which of the following statements regarding flecainide as a treatment of AFib is true?A. It may contribute to an increase in the digoxin level
It may contribute to an increase in the digoxin level. Flecainide (amiodarone, propafenone [Rythmol], and verapamil) can increase digoxin level. Flecainide can regularize and slow the atrial rhythm in patients with AFib and can, therefore, lead to increased ventricular response because of improved conduction of the atrial impulses through the AV node. It is, therefore, important to use an AV nodal blocking agent in patients with AFib treated with flecainide. It is used for AFib as well as flutter; however, it needs to be used with caution in atrial flutter patients, as it may slow the cycle length of the flutter circuit and result in more rapid conduction to the ventricle. There are no definite data on its safety in patients with hypertrophic cardiomyopathy. It is effective for acute conversion as well as maintenance of NSR postconversion.