Urology>>>>>Renal Pathophysiology
Question 10#

Which of the following is TRUE regarding biochemical pathology of urine?

A. Tamm-Horsfall protein is secreted by renal epithelial cells in the loop of Henle and the proximal convoluted tubule as a membrane-anchored protein
B. Nephrocalcin is an acidic glycoprotein containing predominantly acidic amino acids that is synthesised in the thick ascending limb and distal tubule
C. Uropontin is an acidic phosphorylated glycoprotein expressed in bone matrix and renal epithelial cells of the ascending limb of the loop of Henle and the distal tubule
D. Polyanions including glycosaminoglycans, acid mucopolysaccharides and RNA have been shown to inhibit crystal growth but not nucleation
E. Among the glycosaminoglycans, heparan sulfate interacts most strongly with calcium phosphate crystals

Correct Answer is C

Comment:

Answer C