Which of the following drugs have shown efficacy in the treatment of ‘hot flushes’ following hormonal treatment for advanced prostate cancer?a. Diethylstilbestrol
Medroxyprogesterone 20 mg od has been shown to significantly reduce hot flushes; cyproterone acetate also reduces flushes.
Irani J et al. Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: A double-blind, randomised trial. Lancet Oncol 2010; 11(2): 147–154.