Urology>>>>>Prostate Cancer
Question 5#

Which of the following drugs have shown efficacy in the treatment of ‘hot flushes’ following hormonal treatment for advanced prostate cancer?

a. Diethylstilbestrol
b. 5α-reductase inhibitors
c. Medroxyprogesterone acetate
d. Tamsulosin
e. Clonidine

Correct Answer is C

Comment:

Answer C

Medroxyprogesterone 20 mg od has been shown to significantly reduce hot flushes; cyproterone acetate also reduces flushes.

Further Reading:

Irani J et al. Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: A double-blind, randomised trial. Lancet Oncol 2010; 11(2): 147–154.