Which of the following information on molecular markers in prostate cancer is CORRECT?
A. PCA3, a non-coding RNA, is under expressed in prostate cancerAnswer B
PCA3 is overexpressed in prostate cancer, kallikrein 3 is also known as PSA so rises in metastatic disease, high molecular weight cytokeratin binds basal cells – malignant acini lack basal cells. PSA doubling time and PSA velocity provide limited predictive information over PSA alone in prostate cancer diagnosis.