Critical Care Medicine-Renal, Electrolyte and Acid Base Disorders>>>>>Drug Dosing in Renal Failure
Question 7#

Which of the following antibiotics requires dose adjustment in stage 5 CKD patient?

A. Linezolid
B. Moxifloxacin
C. Ceftriaxone
D. Cefazolin
E. Clindamycin

Correct Answer is D

Comment:

Correct Answer: D

There are multiple antibiotics that have significant nonrenal excretion routes. Antibiotics such as azithromycin, ceftriaxone, clindamycin, doxycycline, linezolid, metronidazole, moxifloxacin, nafcillin, oxacillin, rifampin, and tigecycline do not require dose adjustment in patients with severe renal disease. Cefazolin, on the other hand, requires dose adjustment based on creatinine clearance.

References:

1. Letourneau A, Hooper D, Bloom A. Penicillin, Antistaphylococcal Penicillins, and Broad-Spectrum Penicillins. https://www.uptodate.com/contents/penicillin-antistaphylococcalpenicillins-and-broad-spectrum-penicillins.
2. Lexi–Drug, Lexi–Comp® [Internet database]. Hudson, OH: Lexi–Comp, Inc. Available at http://www.crlonline.com. Accessed October 2018.
3. Stanford Hospital & Clinics Antimicrobial Dosing Reference Guide 2014. Available at http://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/dAccessed October 2018.