A 38-year-old man who recently returned from visiting his family in the Philippines presents to the emergency department with 1 week of fatigue, low-grade fever, abdominal pain, and jaundice. Laboratory results include:
Serology comes back as:
The serology results are most consistent with which of the following?A. Acute hepatitis B infection
Correct Answer: C
The presence of the combination of anti-HBs and anti-HBc IgG with all other hepatitis B markers being negative suggests immunity from a prior infection. Hepatitis B surface antigen (HBsAg) is a marker of current infection. Hepatitis B surface antibody (anti-HBs) is a marker of immunity through vaccination or previous exposure. Hepatitis B core antibody IgG (anti-HBc IgG) is a marker of previous exposure. Hepatitis B core antibody IgM (anti-HBc IgM) is generally a marker of acute HBV infection, although it can also be positive during spontaneous exacerbation of chronic HBV.