Which of the following laboratory findings is MOST likely to be found in a patient diagnosed with antiphospholipid syndrome?A. Platelets 65 × 109/L
Correct Answer: A
Antiphospholipid syndrome is a systemic autoimmune disorder leading to a hypercoagulable state characterized by venous or arterial thrombosis in the presence of evidence of persistent antiphospholipid antibodies (anticardiolipin, anti-beta-2-glycoprotein, lupus anticoagulant). Antiphospholipid syndrome can occur as a primary condition or in the presence of another systemic autoimmune disease.
Diagnosis is made by a combination of clinical factors and laboratory tests:
Other laboratory findings include thrombocytopenia, prolonged aPTT in patients not receiving anticoagulation, and a history of false-positive serologic test for syphilis (antigen used in venereal disease research laboratory [VDRL] and rapid plasma reagin [RPR] tests contains cardiolipin). Leukocyte count and hemoglobin are not specifically associated with antiphospholipid syndrome.