Critical Care Medicine-Hematologic and Oncologic Disorders>>>>>Complications of Immunosuppressive Drugs and Chemotherapy
Question 4#

Which of the following side effects is not commonly associated with tacrolimus?

A. Nephrotoxicity
B. Glucose intolerance
C. Neurotoxicity
D. Adrenal insufficiency
E. Increased likelihood of squamous cell cancer

Correct Answer is D

Comment:

Correct Answer: D

The calcineurin inhibitors cyclosporine and tacrolimus impair the transcription of interleukin-2 and other T cell cytokines. Both drugs exhibit multiple organ toxicities but not adrenal insufficiency. In addition to A-C and E above, these drugs are associated with hypertension, hyperkalemia, hyperlipidemia, infections, nausea/vomiting, and an increased risk of posttransplant lymphoproliferative disorder.

Reference:

1. Magnasco A, Rossi A, Catarsi P, et al. Cyclosporin and organ specific toxicity: clinical aspects, pharmacogenetics and perspectives. Curr Clin Pharmacol. 2008;3:166-173.