Which of the following side effects is not commonly associated with tacrolimus?A. Nephrotoxicity
Correct Answer: D
The calcineurin inhibitors cyclosporine and tacrolimus impair the transcription of interleukin-2 and other T cell cytokines. Both drugs exhibit multiple organ toxicities but not adrenal insufficiency. In addition to A-C and E above, these drugs are associated with hypertension, hyperkalemia, hyperlipidemia, infections, nausea/vomiting, and an increased risk of posttransplant lymphoproliferative disorder.