Successful antibiotic penetration of a burn eschar can be achieved with:
A. Mafenide acetateMafenide acetate is the antibiotic agent that penetrates burn eschar to reach the interface with the patient's viable tissue. This agent has the disadvantages that it is quite painful on any partial thickness areas, and it is a carbonic anhydrase inhibitor that interferes with renal buffering mechanisms. Chloride is retained, and metabolic acidosis results. For these reasons, silver sulfadiazine is more commonly used in burn centers unless a major problem with burn wound sepsis is present.