Question 20#

The most significant side effect of sirolimus is:

A. Anemia
B. Leukopenia
C. Impaired wound healing
D. Hypertriglyceridemia

Correct Answer is D


One of the most significant side effects of sirolimus is hypertriglyceridemia, a condition that may be resistant to statins and fibrates. Impaired wound healing (immediately post-transplant in particular), thrombocytopenia, leukopenia, and anemia also are associated with sirolimus, and these problems are exacrbated when it is used in combination with MMF.