Question 15#
Which of the following is a dominant cytokine in the pathogenesis of systemic inflammatory response syndrome (SIRS)?
A. Interleukin-2 (IL-2)B. IL-5
C. IL-6
D. IL-7
Correct Answer is C
Comment:
The systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS) carry significant mortality risks (Table below).
Mortality associated with patients exhibiting two or more criteria for systemic inflammatory response syndrome (SIRS):
Specific criteria have been established for the diagnosis of SIRS (Table below),
Inclusion criteria for the systemic inflammatory response syndrome:
but two criteria are not required for the diagnosis of SIRS: lowered blood pressure and blood cultures positive for infection. SIRS is the result of proinflammatory cytokines related to tissue mal perfusion or injury.
The dominant cytokines implicated in this process include interleukin (IL)-1, IL-6, and tissue necrosis factor (TNF). Other mediators include nitric oxide, inducible macrophagetype nitric oxide synthase, and prostaglandin 12.