Surgery>>>>>Molecular and Genomic Surgery
Question 5#

In cellular apoptosis, the release of cytochrome c activates the:

A) Fas receptor
B) Death receptor
C) Tumor necrosis factor receptor
D) Caspase cascade

Correct Answer is D

Comment:

A simplified view of the apoptosis pathways (Fig. below). Extracellular death receptor pathways include the activation of Fas and tumor necrosis factor (TNF) receptors, and consequent activation of the caspase pathway. Intracellular death pathway indicates the release of cytochrome c from mitochondria, which also triggers the activation of the caspase cascade. During apoptosis, cells undergo DNA fragmentation, nuclear and cell membrane breakdown, and are eventually digested by other cells.

 A simplified view of the apoptosis pathways. Extracellular death receptor pathways include the activation of Fas and tumor necrosis factor (TNF) receptors, and consequent activation of the caspase pathway. Intracellular death pathway indicates the release of cytochrome c from mitochondria, which also triggers the activation of the caspase cascade. During apoptosis, cells undergo DNA fragmentation, nuclear and cell membrane breakdown, and are eventually digested by other cells.