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Category: Psychiatry--->Psychiatric Genetics
Page: 16

Question 76# Print Question

Which of the following statements comparing the genetics of simple Mendelian disorders and schizophrenia is true?

A. Schizophrenia has higher monozygotic concordance
B. Phenocopies are probably more common in schizophrenia than in Mendelian disorders
C. Locus heterogeneity within families is very common in Mendelian disorders
D. Penetrance is almost always complete in schizophrenia
E. Mendelian disorders always present in childhood


Question 77# Print Question

The term copy number variation refers to:

A. Differences in the number of copies of certain genes per genome
B. Differences in the total number of genes in a genome
C. Differences in genetic code between two normal parents of a diseased child
D. Variations in single nucleotides of a functional genetic code
E. Variations in length of promoter regions of certain transcription factors


Question 78# Print Question

From the following, chose the correct combination of trinucleotide repeats and fragile-X syndrome genotype:

A. 6 to 60 CGG repeats: premutation
B. 61 to 200 CAG repeats: mutation
C. 2 to 20 CGG repeats: permutation
D. >200 CGG repeats: full mutation
E. >49 CCG repeats: full mutation


Question 79# Print Question

Which of the following statements regarding genetic testing for Huntington’s disease is true?

A. Genetic testing cannot predict the probable age of onset of symptoms
B. Direct identification of the trinucleotide repeats is not possible using currently available genetic tests
C. Prenatal testing is not possible for a fetus of non-affected parents
D. The disease does not occur in those with no positive family history of Huntington’s disease
E. Homozygotes are more severely affected than heterozygotes


Question 80# Print Question

A 12-year-old boy presents with clinical features consistent with hyperkinetic disorder with conduct problems. On examination, he has an abnormal spinal curvature. Psychometric testing reveals deficits in linguistic and visuospatial skills with borderline IQ. His younger brother has multiple, light-brown spots on his face.

Which of the following is the likely mode of inheritance?

A. Autosomal dominant
B. Autosomal recessive
C. Trinucleotide expansion
D. X-linked recessive
E. X-linked dominant




Category: Psychiatry--->Psychiatric Genetics
Page: 16 of 16