Multiple Choice Questions (MCQ)

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Category: Urology--->Prostate Cancer
Page: 2

Question 6#Print Question

In the report of the American Joint Committee on Cancer (2018), which of the following is CORRECT?

a. T1c disease may be visible using multiparametric MRI
b. Non-regional lymph node involvement is defined as N2
c. Tumour invading into, but not through, the capsule is defined as pT3a disease
d. pT3b indicates involvement of the seminal vesicles after radical prostatectomy
e. Impalpable prostate cancer present in both lobes in TRUS biopsies is defined as T1b

Question 7#Print Question

Which of the following is TRUE regarding the pathogenesis of prostate cancer?

a. If 2 or more first-degree relatives have prostate cancer the risk of developing the disease increases 5–11 fold
b. It is estimated 20% are hereditary
c. Japanese men have a lower incidence of latent/indolent disease than US men
d. In the US, African American men have a lower incidence and mortality from prostate cancer than White American men
e. Increasing age is not a risk factor for developing prostate cancer

Question 8#Print Question

In the Prostate Cancer Prevention Trial, how many men over 62 years old with a normal PSA (≤4 ng/mL) and a normal rectal examination had prostate cancer on TRUS biopsy and how many men with cancer had Gleason ≥7 disease?

a. 5% and 2.5%
b. 8% and 2%
c. 10% and 5%
d. 15% and 15%
e. 30% and 10%

Question 9#Print Question

Which of the following is CORRECT regarding men with localised prostate cancer treated with radiotherapy?

a. Dose escalation from 70–80 Gy does not affect biochemical survival at 5 years
b. Prophylactic lymph node irradiation improves cancer specific survival in highrisk patients
c. There is no subsequent increased risk of developing bladder cancer
d. Recurrence is defined as a rise in PSA of >1 ng/mL above a PSA nadir
e. In men with Gleason 8–10 disease the use of neoadjuvant and 2 years adjuvant androgen deprivation therapy has a significant effect on 10-year overall mortality

Question 10#Print Question

Which of the following information on molecular markers in prostate cancer is CORRECT?

a. PCA3, a non-coding RNA, is under expressed in prostate cancer
b. Ki-67 antigen is detected by immunohistochemical staining and correlates with outcome after radical prostatectomy
c. Kallikrein 3 level is reduced in metastatic prostate cancer
d. High molecular weight cytokeratin binds to prostate cancer cells confirming the diagnosis of cancer over HGPIN
e. PSA doubling time is a useful tool that outperforms total PSA in the diagnosis of prostate cancer

Category: Urology--->Prostate Cancer
Page: 2 of 2