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Category: Critical Care Medicine-Renal, Electrolyte and Acid Base Disorders--->Drug Dosing in Renal Failure
Page: 2

Question 6#Print Question

A 70-year-old male with mild dementia and history of intravenous drug abuse, currently on methadone, was admitted to the ICU with obstructive nephropathy. Based on the initial workup, it is likely secondary to advanced prostate cancer with metastatic disease to the bones. He has postobstructive renal acute kidney injury and has been admitted for further care. He was placed on his home dose of methadone.

Which of the following is TRUE regarding methadone?

A. Methadone undergoes extensive hepatic metabolism by the cytochrome P450 family
B. Methadone has two main active metabolites
C. The primary elimination of methadone is through the liver
D. In addition to its action on the mu receptors, methadone also acts as an agonist to n-methyl-d-aspartate (NMDA) receptors


Question 7#Print Question

Which of the following antibiotics requires dose adjustment in stage 5 CKD patient?

A. Linezolid
B. Moxifloxacin
C. Ceftriaxone
D. Cefazolin
E. Clindamycin


Question 8#Print Question

A patient with chronic renal failure and 60 % (body surface area) burns is undergoing a 20-minute dressing change in the ICU.

Which of the following opioids has the most favorable profile?

A. Morphine
B. Remifentanil
C. Hydromorphone
D. Meperidine




Category: Critical Care Medicine-Renal, Electrolyte and Acid Base Disorders--->Drug Dosing in Renal Failure
Page: 2 of 2