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Category: Critical Care Medicine-Pharmacology and Toxicology--->Metabolism and Drug Interactions
Page: 2

Question 6# Print Question

A 46-year-old male with a past medical history of COPD and uncontrolled diabetes is intubated and sedated in the ICU requiring inotropic and vasopressor support for septic shock due to pneumonia. Several days into his admission he develops bradycardia that is refractory to treatment, necessitating the placement of a transvenous catheter. Urinalysis is positive for myoglobin and his CK levels approach 50 000 U/L. You obtain a blood gas that reveals a:

  • pH of 7.13
  • PaCO2 39
  • PaO2 88
  • HCO3 13 with a base excess of −8

Propofol infusion syndrome (PRIS) is suspected.

Which of the following is NOT a known triggering factor for this condition?

A. Excessive carbohydrate intake
B. Hydrocortisone therapy
C. Epinephrine infusion
D. Septic shock


Question 7# Print Question

A 62-year-old Cantonese woman with no significant past medical history is admitted to the ICU with intense nausea, vomiting, and diarrhea 24 hours after ingestion of an unknown mushroom. Laboratory studies are negative for Epstein-Barr, all forms of hepatitis, and antinuclear antibody. ALT and AST are elevated. On day 3 of admission, she goes into acute hepatic failure. Mushroom poisoning is suspected.

Which of the following drugs is amatoxin uptake inhibitor?

A. Thioctic acid
B. Erythromycin
C. Silibinin
D. Methylprednisolone


Question 8# Print Question

Which of the following statements is most appropriate when considering the risk of arrhythmias between typical and atypical antipsychotics?

A. Greater risk is seen with atypical antipsychotics compared with typical antipsychotics
B. Greater risk is seen with typical antipsychotics compared with atypical antipsychotics
C. Typical antipsychotics have a greater QTc increase than atypical antipsychotics
D. There is no difference in the risk between the two




Category: Critical Care Medicine-Pharmacology and Toxicology--->Metabolism and Drug Interactions
Page: 2 of 2